Cardiovascular Disease (ApoE) DNA Test

The APOE gene influences both your risk of a heart attack, and your best approach to lower cholesterol levels. Find out your risk and the best treatment option for you.

  Detects variants of the APOE gene

 Buccal swab sample collection


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Free shipping on all orders within the U.S.

What you get with this test

Detailed Description

Cardiovascular diseases (CVD) include heart attack and stroke. Maintaining normal cholesterol levels is essential for the prevention of CVD.

LDL-cholesterol is often referred to as the “bad” cholesterol. It collects in the walls of your blood vessels, where it can cause blockages and scarring known as atherosclerosis. Increased LDL-cholesterol levels put you at greater risk for CVD.

Other contributing factors to CVD include elevated triglycerides (the main form of storage fat in our body) and high levels of other low-density lipoproteins (e.g. beta-very low-density lipoproteins).

Hyperlipoproteinemia type III is one disease characterized by elevated triglycerides and beta-very low-density lipoproteins. It is associated with an early onset of peripheral vascular disease and CVD.

The Genetics

The APOE gene is a major genetic risk factor involved in CVD. It can also influence how well you will respond to dietary changes and blood pressure lowering medications to control your cholesterol levels. It encodes Apolipoprotein E (ApoE), a protein involved in the production, delivery, and utilization of cholesterol in the body. A simple mouth swab is all we need to determine your APOE genotype.

Different Versions of the APOE Gene

There are several different versions or alleles of APOE. The three most common alleles are known as e2e3 and e4. Each of these alleles produces a slightly different version of the ApoE protein.

  • e3: The most common, neutral allele. No increased or decreased risk of cardiovascular disease
  • e4: Associated with an increased risk of high LDL-cholesterol levels and atherosclerosis
  • e2: Associated with lower LDL-cholesterol levels in the blood, but increased risk of high blood sugar and hyperlipoproteinemia type III, leading to a higher risk of cardiovascular disease

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How Does Your APOE Genotype Influence Your Risk of Cardiovascular Disease?

  •  Two copies of the e3 allele:  Not at increased risk of CVD
  •  One e3 allele and one e2 allele: Not at increased risk of CVD
  •  Two copies of the e2 allele: Lower LDL-cholesterol but increased risk of hyperlipoproteinemia type III, which can contribute towards CVD
  •  One or two copies of the e4 allele: Elevated LDL-cholesterol and increased risk of CVD

Different versions of the APOE gene will also affect how a person responds to diet and statins (cholesterol-lowering drugs).

APOE e3/e4 and e4/e4 genotypes:

low-fat diet is recommended for people with the e3/e4 and e4/e4 genotypes, as they are not able to metabolize fats very effectively. These individuals do not respond very well to statins.

APOE e2/e2 or e2/e3 genotypes:

Individuals with the e2/e2 or e2/e3 genotype are able to metabolize fats more efficiently, but have less effective metabolism of carbohydrates. They have a better response to statins.

CLIA Certified

All Genofit tests are guaranteed to be processed by a CLIA certified laboratory–the same type of certification as hospital laboratories.

Physician Reviewed

Genofit tests are reviewed and approved by a third-party independent physician licensed to practice within your state.

HIPAA Compliant

Genofit takes measures to guarantee your privacy. Your personal data is securely stored and will not shared with any third-party without your permission.

Get Started in 3 Easy Steps​

Get Started in 3 Easy Steps

1. Activate Kit

Activate your kit online at by entering the unique activation code found inside your kit.

2. Collect & Mail Sample

Simply collect your sample at home, then mail your sample directly to the lab with free return shipping.

3. View Results

Receive your results within 5-7 business days after the lab receives your kit.


Here are the answers to the most frequently asked questions about this test.

Yes, your results are 100% confidential. No one will be able to access your account or your results unless you give them your confidential account login. You can change the password to your account at any time. Please remember to safeguard your login information and not share it with anyone.
Testing begins immediately the day that your samples arrive at the laboratory. In some special situations, additional testing may be required, which could increase the turnaround time by a few extra days. You can check the status of your test online 24/7 using your secure account login. Your test report is released immediately once testing is complete.
Drinking or eating will not change the results in any way. The reason that you are not supposed to drink or have anything in the mouth for an extended period prior to collection is to ensure that we have enough buccal cells to complete the test. If there are not enough cells to complete the test, then the results will not be released and a recollection will be required.
No. You can send the kits back to the laboratory using any shipping method of your choosing. Please be advised that if you do not use the included prepaid return mailer to ship your samples, it is your responsibility to ensure that your samples arrive at the laboratory. We will not be able to provide assistance for shipments that do not use our prepaid return mailer.

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