Alcohol Intolerance DNA Test

Does your face turn red when you drink? Do you experience severe hangovers from just one drink? If you answered yes, you may be alcohol intolerant. Find out your risk of alcohol intolerance with this DNA test.

  Tests mutations in ADH and ALDH genes

 Buccal swab sample collection


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Free shipping on all orders within the U.S.

What you get with this test

Detailed Description

The majority of the alcohol (aka the chemical ethanol) that enter our body is cleared via a two-step process involving two enzymes.

In the first step of alcohol metabolism, alcohol dehydrogenase (ADH) converts ethanol to acetaldehyde. Acetaldehyde is a toxic chemical. But is usually short-lived, because it is quickly converted to acetate by aldehyde dehydrogenase (ALDH) in the second step of alcohol metabolism. The end product acetate is easily broken down to carbon dioxide and water.

People with genetic variants in the alcohol metabolism pathway either generate acetaldehyde too quickly, or are unable to eliminate it fast enough. This results in the dangerous build up of acetaldehyde in the body, even when moderate amounts of alcohol is consumed.

A simple mouth swab is all we need to find out whether you have inherited DNA changes that affect your ability to metabolize alcohol, and may increase your risk of serious health complications.

The Genetics

People with genetic variants in the alcohol metabolism pathway either generate acetaldehyde too quickly, or are unable to eliminate it fast enough. This results in a dangerous build up of toxic acetaldehyde in the body, even when moderate amounts of alcohol are consumed.

  • ADH1B and ADH1C  – converts ethanol to acetaldehyde (first step of alcohol metabolism). Variants increase ADH enzyme activity leading to the build up of acetaldehyde.
  •  ALDH2 – converts acetaldehyde to acetate (second step of alcohol metabolism). A common variant decreases ALDH enzyme activity, slowing the removal of toxic acetaldehyde.

Health Risk for Heterozygotes

Heterozygotes are people who inherit two different versions of a particular gene. ADH1BADH1C and ALDH2 genes have a cumulative affect. For example,

Individuals with two slow ALDH2 alleles have:

  – Zero detectable ALDH enzyme activity

  – Severe side effects

Heterozygotes for ALDH2 (one fast allele and one slow allele) have:

  – 30-50% reduction in ALDH enzyme activity

  – Moderate side effects

  – An increased risk of health complications

  • 10-fold increase risk of esophageal cancer for moderate drinker
  • 90-fold increased risk for heavy drinkers

CLIA Certified

All Genofit tests are guaranteed to be processed by a CLIA certified laboratory–the same type of certification as hospital laboratories.

Physician Reviewed

Genofit tests are reviewed and approved by a third-party independent physician licensed to practice within your state.

HIPAA Compliant

Genofit takes measures to guarantee your privacy. Your personal data is securely stored and will not shared with any third-party without your permission.

Get Started in 3 Easy Steps​

Get Started in 3 Easy Steps

1. Activate Kit

Activate your kit online at by entering the unique activation code found inside your kit.

2. Collect & Mail Sample

Simply collect your sample at home, then mail your sample directly to the lab with free return shipping.

3. View Results

Receive your results within 5-7 business days after the lab receives your kit.


Here are the answers to the most frequently asked questions about this test.

Yes, your results are 100% confidential. No one will be able to access your account or your results unless you give them your confidential account login. You can change the password to your account at any time. Please remember to safeguard your login information and not share it with anyone.
Testing begins immediately the day that your samples arrive at the laboratory. In some special situations, additional testing may be required, which could increase the turnaround time by a few extra days. You can check the status of your test online 24/7 using your secure account login. Your test report is released immediately once testing is complete.
Drinking or eating will not change the results in any way. The reason that you are not supposed to drink or have anything in the mouth for an extended period prior to collection is to ensure that we have enough buccal cells to complete the test. If there are not enough cells to complete the test, then the results will not be released and a recollection will be required.
No. You can send the kits back to the laboratory using any shipping method of your choosing. Please be advised that if you do not use the included prepaid return mailer to ship your samples, it is your responsibility to ensure that your samples arrive at the laboratory. We will not be able to provide assistance for shipments that do not use our prepaid return mailer.

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