Alcohol Intolerance DNA Test
Does your face turn red when you drink? Do you experience severe hangovers from just one drink? If you answered yes, you may be alcohol intolerant. Find out your risk of alcohol intolerance with this DNA test.
Tests mutations in ADH and ALDH genes
Buccal swab sample collection
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What you get with this test
The majority of the alcohol (aka the chemical ethanol) that enter our body is cleared via a two-step process involving two enzymes.
In the first step of alcohol metabolism, alcohol dehydrogenase (ADH) converts ethanol to acetaldehyde. Acetaldehyde is a toxic chemical. But is usually short-lived, because it is quickly converted to acetate by aldehyde dehydrogenase (ALDH) in the second step of alcohol metabolism. The end product acetate is easily broken down to carbon dioxide and water.
People with genetic variants in the alcohol metabolism pathway either generate acetaldehyde too quickly, or are unable to eliminate it fast enough. This results in the dangerous build up of acetaldehyde in the body, even when moderate amounts of alcohol is consumed.
A simple mouth swab is all we need to find out whether you have inherited DNA changes that affect your ability to metabolize alcohol, and may increase your risk of serious health complications.
People with genetic variants in the alcohol metabolism pathway either generate acetaldehyde too quickly, or are unable to eliminate it fast enough. This results in a dangerous build up of toxic acetaldehyde in the body, even when moderate amounts of alcohol are consumed.
- ADH1B and ADH1C – converts ethanol to acetaldehyde (first step of alcohol metabolism). Variants increase ADH enzyme activity leading to the build up of acetaldehyde.
- ALDH2 – converts acetaldehyde to acetate (second step of alcohol metabolism). A common variant decreases ALDH enzyme activity, slowing the removal of toxic acetaldehyde.
Health Risk for Heterozygotes
Heterozygotes are people who inherit two different versions of a particular gene. ADH1B, ADH1C and ALDH2 genes have a cumulative affect. For example,
Individuals with two slow ALDH2 alleles have:
– Zero detectable ALDH enzyme activity
– Severe side effects
Heterozygotes for ALDH2 (one fast allele and one slow allele) have:
– 30-50% reduction in ALDH enzyme activity
– Moderate side effects
– An increased risk of health complications
- 10-fold increase risk of esophageal cancer for moderate drinker
- 90-fold increased risk for heavy drinkers
All Genofit tests are guaranteed to be processed by a CLIA certified laboratory–the same type of certification as hospital laboratories.
Genofit tests are reviewed and approved by a third-party independent physician licensed to practice within your state.
Genofit takes measures to guarantee your privacy. Your personal data is securely stored and will not shared with any third-party without your permission.
Get Started in 3 Easy Steps
Get Started in 3 Easy Steps
1. Activate Kit
Activate your kit online at genofit.com by entering the unique activation code found inside your kit.
2. Collect & Mail Sample
Simply collect your sample at home, then mail your sample directly to the lab with free return shipping.
3. View Results
Receive your results within 5-7 business days after the lab receives your kit.
Here are the answers to the most frequently asked questions about this test.