Caffeine Sensitivity DNA Test

Ever wonder if you need to cut back your caffeine intake? Discover whether you are a fast or slow caffeine metabolizer with the DNA Caffeine Sensitivity Test.

  Detects Genetic variants in the CYP1A2 gene

 Buccal swab sample collection


Free Shipping • FSA / HSA accepted

Free shipping on all orders within the U.S.

What you get with this test

Detailed Description

Not all of us are equally affected by caffeine. Caffeine sensitivity depends on how long it stays around in our bodies. Some of us are “fast” caffeine metabolizers and clear caffeine much faster, while “slow” metabolizers take longer to clear it from their body.

The longer caffeine stays in the circulation, the higher the risk of a heart attack or high blood pressure (hypertension). By drinking more than 3 cups of coffee per day a slow metabolizer may be increasing their risk of

•  a heart attack by 2- to 4-fold

•  hypertension by 3-fold

Take this simple genetic analysis to determine if caffeine consumption may be harming your health.

The Genetics

Close to 95% of the caffeine in the body is broken down by the CYP1A2 enzyme.

There are two common genetic variants of this enzyme – a “fast” metabolizer variant and a “slow” metabolizer variant.

The “slow” caffeine metabolizer variant

The “slow” genetic variant is associated with lower levels of the CYP1A2 enzyme and a slower rate of caffeine breakdown. People who inherit the “slow” variant take longer to clear caffeine from their body.

The longer the caffeine stays in circulation, the higher the risk of heart problems and hypertension. Reduced caffeine consumption is recommended for “slow” metabolizers.

Effects of Caffeine

Caffeine is the most widely used psychoactive drug in the world. But, unlike other drugs that affect the brain, it’s legal, unregulated, and is available in many different forms.

Once in our bodies, caffeine will

  • bind to receptors on the surface of nerve cells increasing their activity
  • stimulate the pituitary glad to release hormones
  • prompt the adrenal glands to make the “fight or flight” hormone adrenaline

Caffeine also increases the levels of the “feel good” dopamine, a chemical messenger in our brain, activating the pleasure centers of the brain. This increase in dopamine may be behind caffeine addiction.

CLIA Certified

All Genofit tests are guaranteed to be processed by a CLIA certified laboratory–the same type of certification as hospital laboratories.

Physician Reviewed

Genofit tests are reviewed and approved by a third-party independent physician licensed to practice within your state.

HIPAA Compliant

Genofit takes measures to guarantee your privacy. Your personal data is securely stored and will not shared with any third-party without your permission.

Get Started in 3 Easy Steps​

Get Started in 3 Easy Steps

1. Activate Kit

Activate your kit online at by entering the unique activation code found inside your kit.

2. Collect & Mail Sample

Simply collect your sample at home, then mail your sample directly to the lab with free return shipping.

3. View Results

Receive your results within 5-7 business days after the lab receives your kit.


Here are the answers to the most frequently asked questions about this test.

Yes, your results are 100% confidential. No one will be able to access your account or your results unless you give them your confidential account login. You can change the password to your account at any time. Please remember to safeguard your login information and not share it with anyone.
Testing begins immediately the day that your samples arrive at the laboratory. In some special situations, additional testing may be required, which could increase the turnaround time by a few extra days. You can check the status of your test online 24/7 using your secure account login. Your test report is released immediately once testing is complete.
Drinking or eating will not change the results in any way. The reason that you are not supposed to drink or have anything in the mouth for an extended period prior to collection is to ensure that we have enough buccal cells to complete the test. If there are not enough cells to complete the test, then the results will not be released and a recollection will be required.
No. You can send the kits back to the laboratory using any shipping method of your choosing. Please be advised that if you do not use the included prepaid return mailer to ship your samples, it is your responsibility to ensure that your samples arrive at the laboratory. We will not be able to provide assistance for shipments that do not use our prepaid return mailer.

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